Wolfgang Högler Selected Research

Rickets (Rachitis)

1/2022	Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia.
1/2022	Effect of Burosumab Compared With Conventional Therapy on Younger vs Older Children With X-linked Hypophosphatemia.
1/2021	Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia.
10/2020	Nutritional rickets & osteomalacia: A practical approach to management.
4/2020	New Developments in the Treatment of X-Linked Hypophosphataemia: Implications for Clinical Management.
1/2020	Oral Iron for Prevention and Treatment of Rickets and Osteomalacia in Autosomal Dominant Hypophosphatemia.
1/2019	Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial.
1/2019	Spot the silent sufferers: A call for clinical diagnostic criteria for solar and nutritional osteomalacia.
1/2018	Burosumab Therapy in Children with X-Linked Hypophosphatemia.
1/2018	Cardiac, bone and growth plate manifestations in hypocalcemic infants: revealing the hidden body of the vitamin D deficiency iceberg.

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Wolfgang Högler Research Topics

Disease

19	Rickets (Rachitis) 01/2022 - 06/2007
8	Vitamin D Deficiency 10/2020 - 03/2010
8	Osteomalacia 10/2020 - 06/2015
7	Osteogenesis Imperfecta (Lobstein Disease) 12/2021 - 10/2009
7	Pain (Aches) 01/2021 - 01/2007
6	Osteoporosis 07/2022 - 03/2010
6	Hypophosphatasia 11/2020 - 06/2007
5	Congenital Abnormalities (Deformity) 01/2022 - 01/2015
4	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2022 - 01/2018
4	Metabolic Bone Diseases (Osteopenia) 10/2019 - 02/2007
4	Seizures (Absence Seizure) 01/2017 - 02/2007
3	Hypophosphatemia 01/2022 - 01/2018
2	Chronic Disease (Chronic Diseases) 07/2022 - 04/2014
2	Phenylketonurias (Phenylketonuria) 06/2021 - 04/2021
2	Pseudohypoaldosteronism 05/2021 - 05/2013
2	Hypocalcemia 01/2021 - 01/2018
2	Nephrocalcinosis 01/2021 - 06/2007
2	Hypoparathyroidism 01/2021 - 01/2018
2	Disease Progression 02/2019 - 02/2007
2	Hypercalcemia (Milk Alkali Syndrome) 01/2018 - 06/2007
2	Body Weight (Weight, Body) 01/2018 - 03/2010
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017 - 06/2015
2	Liver Diseases (Liver Disease) 03/2012 - 03/2010
2	Bone Resorption 03/2010 - 05/2003
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2022
1	Abscess 01/2022
1	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2022
1	Rare Diseases (Rare Disease) 01/2021
1	Postmenopausal Osteoporosis 01/2021
1	Diarrhea 01/2021
1	type 1 familial Hypocalciuric hypercalcemia 01/2021
1	Fatigue 01/2021
1	Hyperphosphatemia 01/2021
1	Hyperparathyroidism 01/2021
1	Hypopituitarism (Sheehan's Syndrome) 01/2021
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 01/2021
1	Metabolic Diseases (Metabolic Disease) 11/2020
1	Hematologic Diseases (Blood Diseases) 01/2020
1	Leukemia 01/2020
1	Osteosarcoma (Osteogenic Sarcoma) 10/2019
1	Adrenocortical Carcinoma 03/2019
1	Failure to Thrive 02/2019
1	Acute Kidney Injury (Acute Renal Failure) 01/2018
1	Heart Arrest (Cardiac Arrest) 01/2018
1	Neoplasm Metastasis (Metastasis) 01/2018
1	Osteonecrosis (Kienbock's Disease) 01/2018

Drug/Important Bio-Agent (IBA)

15	CalciumIBA 01/2021 - 11/2013
11	Vitamin D FDA LinkGeneric 01/2022 - 11/2013
10	Alkaline PhosphataseIBA 01/2022 - 05/2003
7	Phosphates (Orthophosphate)IBA 01/2022 - 09/2015
7	Parathyroid Hormone (Parathormone)IBA 01/2021 - 03/2010
5	burosumabIBA 01/2022 - 01/2018
5	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 11/2020 - 06/2007
4	Fibroblast Growth Factor-23IBA 01/2022 - 01/2018
4	Phosphorus (Red Phosphorus)IBA 01/2021 - 09/2015
4	Dietary CalciumIBA 10/2020 - 01/2016
4	Diphosphonates (Bisphosphonates)IBA 01/2018 - 12/2015
3	SteroidsIBA 07/2022 - 10/2013
3	SaltsIBA 01/2022 - 02/2012
3	Monoclonal AntibodiesIBA 01/2022 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 04/2021 - 10/2009
3	Pharmaceutical PreparationsIBA 01/2021 - 02/2007
3	MicronutrientsIBA 01/2020 - 01/2016
3	EnzymesIBA 01/2019 - 03/2010
2	Calcitriol (Calcijex)FDA LinkGeneric 01/2022 - 09/2015
2	Hormones (Hormone)IBA 01/2021 - 01/2021
2	asfotase alfaIBA 11/2020 - 01/2019
2	IronIBA 01/2020 - 09/2015
2	MineralsIBA 01/2019 - 09/2007
2	Zoledronic Acid (Zometa)FDA Link 01/2018 - 09/2007
2	Pamidronate (Aredia)FDA LinkGeneric 01/2018 - 01/2016
2	Collagen Type I (Type I Collagen)IBA 12/2016 - 01/2016
2	25-hydroxyvitamin DIBA 11/2013 - 03/2010
2	Cholecalciferol (Vitamin D3)FDA Link 03/2012 - 03/2010
2	Ergocalciferols (Ergocalciferol)FDA LinkGeneric 03/2012 - 03/2010
1	alpha2 Subunit Collagen Type IIBA 12/2021
1	RNA Splice SitesIBA 12/2021
1	N-benzyl-N-methyl-dodecan-1-amineIBA 06/2021
1	Epithelial Sodium ChannelsIBA 05/2021
1	caseinomacropeptideIBA 04/2021
1	NitrogenIBA 04/2021
1	Amino Acids FDA Link 04/2021
1	Calcium-Sensing ReceptorsIBA 01/2021
1	ametantrone (HAQ)IBA 11/2020
1	EndopeptidasesIBA 04/2020
1	Complementary DNA (cDNA)IBA 10/2019
1	Androstenedione (4 Androstene 3,17 dione)IBA 03/2019
1	PHEX Phosphate Regulating Neutral EndopeptidaseIBA 01/2019
1	benzoyl L-arginine methyl ester (BAME)IBA 01/2018
1	Denosumab FDA Link 01/2018
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2018
1	LigandsIBA 01/2018

Therapy/Procedure

15	Therapeutics 01/2022 - 01/2007
2	Aftercare (After-Treatment) 01/2018 - 01/2007
2	Liver Transplantation 03/2012 - 03/2010
1	Diet Therapy (Therapy, Diet) 06/2021
1	Hematopoietic Stem Cell Transplantation 01/2020
1	Orthopedic Procedures 02/2019
1	Drug Therapy (Chemotherapy) 01/2018